Extremophiles, exemplified by (hyper)thermophilic bacteria, possess immense potential as industrial catalysts due to their proficiency in breaking down diverse raw biomaterials. In our laboratory, we concentrate on crafting a thermophilic platform host, equipped with sophisticated genetic tools, to investigate and manipulate microbial enzymes. This enables precise adjustments to their metabolism. A fundamental comprehension of cellular bioenergetic metabolism is paramount for orchestrating metabolic flux through pathway-reprogramming, ultimately yielding high-value products. Also, we do design and engineer robust enzymes such as collagenases with the knowledge, to develop bioprocess using novel biocatalysts. Noteworthy species within our purview include the oil-degrading Geobacillus and the keratin-degrading Thermotogales (Fervidobacterium, etc.).
RESEARCH TOPICS
- Development of genetic tool specialized for metabolic engineering of extremophiles
